SynthesisFrontiers in medicine2026
The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Insulin resistance in the early pregnancy stage can independently lead to the occurrence of gestational diabetes mellitus and adverse pregnancy outcomes. To evaluate the relationship between the Triglyceride-Glucose (TyG) index in early pregnancy and pregnancy complications and adverse pregnancy outcomes using meta-analysis. Methods: Search the CNKI, Wanfang, VIP, China Biomedical Literature database, PubMed, Embase, Web of Science, and the Cochrane Library. The search covered the period from the establishment of each database to December 28, 2025. Two researchers using the Newcastle-Ottawa Scale to assess the quality of the included studies and extracted data. Statistical analysis was performed using RevMan 5.4 and Stata 17.0. Results: Twenty-three studies were included, involving 220,985 participants with 61,774 exposed individuals. Meta-analysis revealed that compared with low TyG index in early pregnancy, high TyG index was significantly associated with increased risks of gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia ( Conclusion: A high TyG index in early pregnancy is significantly positively associated with the occurrence of gestational diabetes, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia. The TyG index can serve as a simple and reliable indicator for the early diagnosis of high-risk pregnancies in pregnant women, facilitating timely clinical intervention by healthcare providers to reduce the incidence of pregnancy complications and adverse pregnancy outcomes. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261293271, Identifier CRD420261293271.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.