ArticleArchives of medical science : AMS2026
Unraveling the impact of neonatal jaundice on allergic diseases: a Mendelian randomization study.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Neonatal jaundice, a condition characterized by elevated bilirubin levels in newborns, is prevalent, affecting up to 60% of term infants. Previous observational studies have linked neonatal jaundice to an enhanced risk of allergic diseases such as asthma, atopic dermatitis (AD), allergic conjunctivitis (AC), allergic rhinitis (AR), and urticaria. However, the causal relationship remains unclear due to potential confounding factors and reverse causality. Material and methods: We conducted a two-sample MR analysis using genetic variants as instrumental variables. Data from large-scale GWAS in European populations were used, including exposure data for neonatal jaundice and outcome data for five common allergic diseases. MR analysis was performed using the inverse variance weighted (IVW) method, with additional sensitivity analyses conducted using MR-Egger regression, weighted median, simple mode, and weighted mode methods. Results: MR analysis revealed a significant causal association between neonatal jaundice and an increased risk of AD (OR = 1.0141, 95% CI: 1.0041-1.0241, Conclusions: This study provides evidence for a causal association between neonatal jaundice and an increased risk of AD and AC. These findings suggest that neonatal jaundice may be a modifiable risk factor for AD and AC, highlighting the importance of neonatal jaundice management and further research on potential preventive strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.