ArticleArchives of medical science : AMS2026
Weekend warrior physical activity patterns can reduce the risk of gallstone formation: NHANES 2017-2020 and Mendelian randomization analyses.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Physical activity (PA) has a significant impact on gallstone formation, but the relationship is still unclear, and the patterns of PA have received little attention. This study aimed to examine the potential association between PA patterns and gallstone disease (GSD). Material and methods: This study conducted two-sample Mendelian randomization (MR) analyses to assess the causal relationships between PA and GSD, cholecystectomy, and biliary tract disorders. The inverse variance weighting (IVW) method was employed as the primary reference, supplemented with sensitivity tests. Subsequently, validation was performed using data from the National Health and Nutrition Examination Survey (NHANES) for the period 2017-2020, from which four PA patterns (no activity, insufficient exercise, weekend warrior, regular exercise) were derived to investigate the association between the weekend warrior pattern and the risk of GSD and cholecystectomy. Results: The MR analysis showed significant causal relationships between PA and GSD (OR = 0.97, 95% CI = 0.94-0.99, Conclusions: A negative causal relationship between PA and GSD was observed. Both weekend warrior and regular exercise were found to effectively reduce the risk of GSD.
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