Evidence map›Paper›PMID 42111006›Full record

ArticleBiomedical optics express2026

Vis-OCT Explorer: an open-source software for visible-light optical coherence tomography data processing.

Weijia Fan, Fengyuanshan Xu, Roman Kuranov, Ronald Zambrano, Jacqueline Chen, Fabio Lavinsky, Jiahui Wu, Seung Hyen Lee, Kenny Q Trang, Rukhsana Mirza and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Weijia FanDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID https://orcid.org/0009-0002-8173-0760
Fengyuanshan XuDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Roman KuranovDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Ronald ZambranoGlaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
Jacqueline ChenGlaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
Fabio LavinskyGlaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
Jiahui WuDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID https://orcid.org/0000-0002-1812-4488
Seung Hyen LeeDepartment of Ophthalmology, University of California, San Diego, CA, USA.
Kenny Q TrangSpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Rukhsana MirzaDepartment of Ophthalmology, Northwestern University, Chicago, IL, USA.
Shira SimonDepartment of Ophthalmology, Northwestern University, Chicago, IL, USA.
Xiaorong LiuDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Jeffrey L GoldbergSpencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Alex S HuangDepartment of Ophthalmology, University of California, San Diego, CA, USA.
Joel S SchumanGlaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.
Hao F ZhangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID https://orcid.org/0000-0001-5089-1196

Funding

Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
NEI NIH HHS R01 EY013178
6 · The paper itself

Abstract

Visible-light OCT provides enhanced retinal imaging resolution, yet achieving clinically dependable, high-quality images requires specialized post-processing methods. We developed Vis-OCT Explorer, an open-source, modular Python software package for vis-OCT image reconstruction and post-processing. In addition to standard spectral-domain OCT processing steps (k-space resampling, dispersion compensation, and Fourier transformation), it incorporates dual-spectrometer balanced detection, short-time Fourier transform (STFT)-based dispersion compensation coefficient optimization, and GPU-accelerated processing. We evaluated reconstruction performance using an intensity-based tissue contrast index and demonstrated that balanced detection significantly improved image quality. To further validate reconstruction reliability, we assessed retinal thickness measurement repeatability across five operators using intraclass correlation coefficient (ICC) analysis. Retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) measurements demonstrated good repeatability across all operators (ICC > 0.8). Specifically, 87.5% of RNFL and GCIPL measurements from four macula-centered images exceeded this threshold. All RNFL measurements from four optic nerve head (ONH)-centered images also exceeded an ICC of 0.8, indicating strong cross-user repeatability. These results demonstrate that Vis-OCT Explorer delivers high-quality reconstruction that enables reliable quantitative measurements, supporting future multicenter clinical studies and vis-OCT data standardization.

Identifiers

PMID42111006
PMCPMC13155850

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.