ArticleFrontiers in cardiovascular medicine2026
Carotid plaque formation prediction model and validation: a case-control study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Carotid plaque serves as an early window into atherosclerosis; however, more convenient tools for plaque risk stratification are currently lacking. This study aimed to investigate the risk factors for carotid plaque occurrence, establish a predictive model, and develop a risk assessment scale. Methods: A total of 12,391 individuals who underwent health examinations at the Physical Examination Center of the First Affiliated Hospital of Xinjiang Medical University between January 2024 and March 2025 were retrospectively enrolled. After applying inclusion and exclusion criteria, Least Absolute Shrinkage and Selection Operator (LASSO) regression was performed. The cohort was then randomly divided into a development set ( Results: In the multivariate regression model adjusted for confounding factors within the development set, female sex (OR = 0.59) and high-density lipoprotein cholesterol (HDL-c) >1.55 mmol/L (OR = 0.80) were associated with a reduced risk of plaque. Age 45-59 years (OR = 5.19), age ≥60 years (OR = 14.04), and smoking (OR = 1.37) were independently associated.
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