ArticleFrontiers in nutrition2026
Risk of gastrointestinal intolerance and complications associated with homemade versus commercial enteral nutrition in critically ill patients: a single-center retrospective cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Critically ill ICU patients often fail to achieve target caloric intake due to gastrointestinal intolerance. Although commercial enteral nutrition (CEN) formulas are the standard of care, emerging evidence suggests they may worsen intolerance in certain susceptible populations. Individualized commercial formulation (ICF) may help reduce related complications, but its safety and effectiveness compared to commercial formulas remain insufficiently validated. Objective: To compare the associations of CEN, mixed feeding, and ICF with gastrointestinal tolerance and complication risk in ICU patients. Methods: In this single-center retrospective cohort study, 605 adult ICU patients receiving tube-fed EN at Henan Provincial People's Hospital between January 2023 and January 2025 were included. Patients were classified into Commercial ( Results: Compared with the Commercial group, the ICF group had a lower incidence of diarrhea (13.6% vs. 41.5%; aOR = 0.27, 95% CI 0.11-0.68; Conclusion: In critically ill ICU patients, ICF was associated with improved gastrointestinal tolerance and lower risks of diarrhea and selected complications compared with CEN. However, these findings should be interpreted cautiously given the observational design.
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