ArticleFrontiers in immunology2026
Polymeric immunoglobulin receptor deficiency attenuates experimental atherosclerosis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
Background: Polymeric immunoglobulin receptor (PIGR) is a transmembrane protein widely expressed in mucosal epithelial cells that is involved in the transcytosis of the polymeric immunoglobulins IgA and IgM. Recent findings revealed increased plasma PIGR levels in subjects with subclinical atherosclerosis, although its function remains uncertain. Purpose: To assess the role of PIGR in atherosclerosis. Methods: We analyzed PIGR levels in human atherosclerotic plaques compared to healthy aortic samples, as well as in the serum of subjects with peripheral arterial disease (PAD) and controls. Next, we studied the effect of germline Results: PIGR levels were increased in the intima of early human atherosclerotic lesions and in patients with PAD, compared to controls. Conclusions: Global
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