Evidence map›Paper›PMID 42112379›Full record

ReviewFrontiers in immunology2026

Mechanisms and treatments of lymphedema.

He Ren, Yanhong Gong, Shuting Zhang, Jing Liu, Jiahe Shen, Oksana Gizinger, Tamara Aripova, Ju Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

He RenMedical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.
Yanhong GongDepartment of Stomatology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Shuting ZhangMedical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.
Jing LiuLaboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Jiahe ShenMedical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.
Oksana GizingerDepartment of Immunology and Allergology, Medical Institute, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Tamara AripovaInstitute of Immunology and Human Genomics, Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan.
Ju LiuMedical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphedema refers to the interstitial edema caused by obstruction of lymph drainage. The clinical symptoms of lymphedema include local swelling and pain, thickened and rough skin, limited walking and repeated infection. Genetic mutation, fat deposition, aging and lymphatic filariasis may contribute to the pathogenesis of lymphedema. CD4

Indexed as

LymphedemaAnimalsCD4-Positive T-LymphocytesEndothelial CellsHumansLymphangiogenesisLymphatic VesselsSignal TransductionVascular Endothelial Growth Factor Receptor-3Vascular Endothelial Growth Factor Receptor-3CD4+T cellslymphangiogenesislymphatic endothelial cellslymphedemapathophysiologytherapy

Identifiers

PMID42112379
PMCPMC13149137

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.