ArticleFrontiers in microbiology2026
Genomic and functional analysis of stress-responsive prophages in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Introduction: Bacteriophages are pervasive components of natural whey starters (NWS) used in traditional hard cheese production, yet their functional role under cheesemaking-related stresses remains poorly understood. Methods: In this study, six temperate bacteriophages associated with Results: Across conditions, stress exposure elicited phage-specific and dose-dependent responses, frequently revealing a decoupling between early increases in phage genomic copy number and subsequent virion release. Heat shock emerged as the most consistent inducer of prophage activation, whereas lactic acid and oxidative stress produced threshold-dependent or inhibitory effects, particularly at higher intensities. Nutrient limitation alone had limited impact, suggesting a permissive rather than triggering role. Discussion: Overall, these findings support a non-binary model of prophage induction, spanning intermediate states from partial genome replication to productive lytic cycles, strongly constrained by host physiological status. Our results indicate that
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