ArticleFrontiers in microbiology2026
Gut microbiota pathways linking primary sclerosing cholangitis to colorectal cancer: the
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Primary sclerosing cholangitis (PSC) increases the risk of CRC, but the biological link is not well understood. Changes in the gut-liver axis, including gut microbiota and microbial metabolites, may contribute to CRC development in PSC. Objective: To explore pathways connecting PSC with CRC through gut microbiota signals, and to identify candidate host genes for follow-up analyses. Methods: Mendelian randomization (MR) was used to estimate the causal effect of genetically predicted PSC on CRC risk and to test associations between PSC liability and gut microbial traits. Mediation analyses were performed to assess whether specific microbial features may contribute to the PSC-CRC association. Single-cell RNA sequencing (scRNA-seq) data from PSC and CRC were integrated to screen candidate host genes, which were further evaluated using survival analyses and immunohistochemistry. Results: MR supported a causal association between PSC and higher CRC risk ( Conclusion: These findings provide supportive evidence that gut microbiota changes and host gene signals are linked to the PSC-CRC association.
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