ReviewFrontiers in antibiotics2026
Microbial interactions of EDTA: recent advances and biological applications in the context of natural product modulation.
Review in Frontiers in antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objectives: Ethylenediaminetetraacetic acid (EDTA) and its salts have been the choice of chelating agents since the 1940s. This review presents an updated details of their synthesis, general biology, ecotoxicological aspects, and applications as antimicrobial and antibacterial agents in combination with natural products. Methods: Relevant research papers were retrieved from PubMed, Web of Science, and Google Scholar through November 2025. Experimental uses of EDTA were excluded. The search terms used were "EDTA" AND "ECOTOXICOLOGY"; "EDTA" AND "GENOTOXICITY"; "EDTA" AND "ANTIMICROBIAL ACTIVITY"; "EDTA" AND "ANTIBACTERIAL ACTIVITY" AND "DENTAL" and "EDTA" AND "ANTICANCER ACTIVITY", "EDTA IN COMBINATION WITH NATURAL PRODUCTS". Results: Sodium/calcium salts of EDTA are water soluble, and their antiseptic efficacy is pH-dependent. They are effective against both Gram-positive and Gram-negative bacteria, as well as pathogenic yeasts, and adversely affect bacterial cell walls, thereby destabilizing biofilms. Multiple nature-derived compounds and standard antibiotics, in combination with EDTA and other therapeutic agents, minimize biofilms in intravascular and urinary catheters. It chelates various metal ions (including heavy metals) into a redox-inactive state, and thereby reduce their toxicity. Furthermore, it was shown to enhance the antimicrobial and antibacterial efficacy of various natural therapeutics when used together. Interpretation and conclusions: EDTA is a stable, readily available, affordable and comparatively safer chelating agent with antibacterial, antifungal, and antibiofilm properties. EDTA is now found to produce a synergistic effect when combined with natural therapeutics on their antimicrobial/antibiofilm activities. This approach proved fruitful in enhancing the capabilities of natural antibiotics against multidrug-resistant bacteria and in reducing the toxic effects of EDTA.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.