ArticleFrontiers in cellular and infection microbiology2026
Association between objectively measured physical activity and maternal stool microbiota during pregnancy: results from a preliminary investigation.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study investigated the relationship between objectively measured physical activity (PA) and gut microbiota composition during pregnancy. Methods: In an ongoing birth cohort study, the Fitbit Charge wearable activity monitor was used to objectively measure PA during pregnancy. To profile the composition of gut bacterial microbiota, 16S rRNA sequencing was performed on a third trimester stool sample. Differences in alpha diversity metrics (richness, Pielou's evenness, and Faith's phylogenetic diversity) by PA were determined using linear regression, whereas beta diversity (unweighted and weighted UniFrac, Canberra, and Bray-Curtis) relationships were assessed using permutational multivariate analysis of variance (PERMANOVA). Differential abundance testing at both the amplicon sequence variants and genus level was conducted using Analysis of Compositions of Microbiomes with Bias Correction 2; tests were corrected for false discovery rate (FDR) and considered significant if p Results: The analytic sample included 68 pregnant women with both PA and 16S rRNA sequencing data (median age [quartile 1; quartile 3] = 30.7 [26.6; 33.3] years; 56% Black). Women typically took around 5000 steps per day (second trimester median = 5486; third trimester median = 5074) and the majority of activity minutes were classified as sedentary (second trimester median = 77%; third trimester median = 78%). None of the PA variables during the second or third trimester were associated with gut microbiota richness, evenness, or diversity. After covariate adjustment, the proportion sedentary during the second (Weighted UniFrac p = 0.035, R Conclusions: These findings highlight sedentary behavior as a potential modifiable factor related with maternal gut microbiota composition during pregnancy. This study forms the basis for future studies on the impact of sedentary time on gut microbiota during pregnancy.
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