Evidence map›Paper›PMID 42112461›Full record

ArticleFrontiers in cellular and infection microbiology2026

Potential value of oral Mogibacterium in major depressive disorder.

Fengyun Wang, Guangjun Xi, En Zhao, Yongtao Yu, Lei Li, Mengmeng Zhong, Pan Wang, Yunuo Chen, Hui Weng, Lixiang Yang and 3 more

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fengyun Wang *Department of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Guangjun Xi *Department of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
En Zhao *Department of Gastroenterology, Xishan People's Hospital of Wuxi City, Wuxi, China.
Yongtao Yu *Comprehensive Stroke Center, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Lei LiDepartment of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Mengmeng ZhongDepartment of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Pan WangDepartment of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Yunuo ChenDepartment of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Hui WengDepartment of Psychology and Sleep Medicine, The Second Hospital of Anhui Medical University, Hefei, China.
Lixiang YangDepartment of Neurosurgery, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Meilei WangDepartment of Neurology, Xishan People's Hospital of Wuxi City, Wuxi, China.
Yachen ShiDepartment of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, China.
Gaojia ZhangDepartment of Psychology and Sleep Medicine, The Second Hospital of Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Major depressive disorder (MDD) is characterized by substantial clinical heterogeneity. Oral microbiota can provide real-time information relevant to the early identification of disease risk and the prediction of therapeutic outcomes. The present study aimed to characterize the specific profiles of oral microbiota in the buccal mucosa of patients with MDD and to explore potential mechanisms linking oral microbiota to the pathophysiology of MDD. Method: A total of 38 patients with MDD and 30 healthy controls (HCs) were enrolled. All MDD patients received standard antidepressant treatment and were followed up at two time points (2 weeks and 6 weeks). Neuropsychological assessments were administered, and 16S rRNA sequencing was employed to determine the abundance of oral bacteria. Results: (1) Significant differences in the diversity of oral microbiota from the buccal mucosa were observed between the MDD and HC groups. (2) The relative abundances of the oral genera Conclusion: Oral

Indexed as

Major Depressive DisorderMicrobiotaMouth MucosaAdultAntidepressive AgentsBacteriaBrain-Derived Neurotrophic FactorFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SVascular Endothelial Growth Factor AAntidepressive AgentsBrain-Derived Neurotrophic FactorRNA, Ribosomal, 16SVascular Endothelial Growth Factor Amajor depressive disorderMogibacteriumneuroplasticityneurotrophinoral microbiota

Identifiers

PMID42112461
PMCPMC13153035

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.