Evidence map›Paper›PMID 42112503›Full record

ReviewThe World Allergy Organization journal2026

Epigenetic insights into food allergy: The potential role of DNA methylation in diagnosis and management.

So Lim Kim, Alana V Beadell, Christina E Ciaccio

Abstract readReview
In one paragraph

Review in The World Allergy Organization journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

So Lim KimSection of Allergy, Immunology, and Pediatric Pulmonology Department of Pediatrics, University of Chicago 5841 South Maryland Avenue, MC 5042 Chicago, IL 60637, USA.
Alana V BeadellDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Christina E CiaccioSection of Allergy, Immunology, and Pediatric Pulmonology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in epigenetics have provided critical insights into mechanisms underlying complex immune-mediated diseases. DNA methylation, a key epigenetic modification found across eukaryotes, serves as a crucial regulator linking genetic predisposition with environmental exposures. This review provides an overview of current methods for detecting 5-methylcytosine and summarizes studies investigating the role of DNA methylation in food allergy. Specifically, studies have examined DNA methylation as a potential biomarker of clinical reactivity, tolerance, and disease severity, and as a regulator of pathways influencing allergic susceptibility. Interpretation across studies remains limited by several factors including methodological variability, small sample sizes, and inconsistent validation. Large-scale, standardized investigations are needed to confirm early findings and facilitate translation into clinical practice.

Indexed as

5-MethylcytosineDNA methylationEpigenomicsFood hypersensitivity

Identifiers

PMID42112503
PMCPMC13156985

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.