Evidence map›Paper›PMID 42112964›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Targeting ALDH7A1 with covalent inhibitors reveals new chemical space for prostate cancer therapy.

Raffaella Gallo, Antonio Scarano, Eleonora Gianquinto, Gaia Franzini, Giulia Antonini, Serena Montalbano, Camillo Palmieri, Paola Conti, Francesca Spyrakis, Chiara Borsari and 1 more

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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raffaella GalloDepartment of Experimental and Clinical Medicine, "Magna Græcia" University of Catanzaro, Catanzaro, Italy.
Antonio ScaranoDepartment of Food and Drug, University of Parma, Parma, Italy.
Eleonora GianquintoDepartment of Drug Science and Technology, University of Turin, Turin, Italy.
Gaia FranziniBiopharmanet-TEC, University of Parma, Parma, Italy.
Giulia AntoniniDepartment of Pharmaceutical Sciences, University of Milan, Milan, Italy.
Serena MontalbanoDepartment of Pharmaceutical Sciences, University of Milan, Milan, Italy.
Camillo PalmieriDepartment of Experimental and Clinical Medicine, "Magna Græcia" University of Catanzaro, Catanzaro, Italy.
Paola ContiDepartment of Pharmaceutical Sciences, University of Milan, Milan, Italy.
Francesca SpyrakisDepartment of Drug Science and Technology, University of Turin, Turin, Italy.
Chiara BorsariDepartment of Pharmaceutical Sciences, University of Milan, Milan, Italy.
Stefano BrunoDepartment of Food and Drug, University of Parma, Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) remains a major global health burden. Although androgen deprivation and receptor-targeted therapies initially benefit patients, resistance often leads to metastatic castration-resistant prostate cancer, with limited treatment options. Aldehyde dehydrogenase 7A1 (ALDH7A1) is an emerging oncogenic driver of PCa, but selective inhibitors are lacking. Here, we report irreversible ALDH7A1 inhibitors targeting the catalytic Cys330, identified from a library of 3-bromo-4,5-dihydroisoxazole derivatives. These compounds show minimal inhibition of ALDH4A1 and GAPDH, supporting selectivity for ALDH7A1. Compounds

Indexed as

Aldehyde DehydrogenaseAntineoplastic AgentsEnzyme InhibitorsProstatic NeoplasmsAldehyde Dehydrogenase 1 FamilyCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMaleMolecular StructureStructure-Activity RelationshipAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyALDH7A1 protein, humanAntineoplastic AgentsEnzyme Inhibitors3-halo-4,5-dihydroisoxazolesaldehyde dehydrogenase isoformsALDH7A1 selective inhibitioncatalytic cysteine targetingcovalent enzyme inhibitors

Identifiers

PMID42112964
PMCPMC13162559

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.