Evidence map›Paper›PMID 42113350›Full record

ArticleMolecular biology reports2026

Caffeic acid phenethyl ester attenuates phenotypic switching and inflammation in abdominal aortic aneurysm via the NF-κB pathway.

Yuanyuan Gu, Chunshui Cao, Jian Liu, Yong Liu, Liang Huang, Zuan Zhan

Abstract read
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In one paragraph

Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuanyuan Gu *Emergency Department, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Chunshui Cao *Emergency Department, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Jian LiuEmergency Department, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Yong LiuEmergency Department, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Liang HuangEmergency Department, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. huangliang6312@sina.com.
Zuan ZhanEmergency Department, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. ndyfy02276@ncu.edu.cn.

Funding

National Natural Science Foundation of China 82260101
6 · The paper itself

Abstract

backgroundIn our previous animal experiments, we found that caffeic acid phenethyl ester (CAPE) inhibited the early formation of elastase-induced abdominal aortic aneurysms (AAA) in rats. However, its efficacy in the angiotensin II (Ang II)-induced AAA model and the underlying mechanism remain unclear. Therefore, the primary aim of this study was to further validate the potential mechanism of CAPE through in vivo and in vitro experiments utilizing Ang II. METHODS AND

resultsApoE

conclusionsCAPE mitigates the progression of AAA in mice and counteract the abnormal cell phenotype and inflammatory responses in Ang II-stimulated MOVAS cells. These protective effects might be achieved by inhibiting the NF-κB pathway.

Indexed as

Aortic Aneurysm, AbdominalCaffeic AcidsNF-kappa BPhenylethyl AlcoholActinsAngiotensin IIAnimalsApoptosisCell MovementCell ProliferationDisease Models, AnimalInflammationMaleMiceMice, Inbred C57BLMyocytes, Smooth MuscleActinsAngiotensin IIcaffeic acid phenethyl esterCaffeic AcidsNF-kappa BOsteopontinPhenylethyl AlcoholAbdominal Aortic AneurysmCaffeic Acid Phenethyl EsterNF-κB pathwayPhenotypic changes

Identifiers

PMID42113350

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.