Evidence map›Paper›PMID 42114558›Full record

ArticleAmerican journal of veterinary research2026

Establishing a standardized biorepository across 3 clinical and translational science center-affiliated veterinary institutions is feasible and productive.

LaTasha K Crawford, Molly E Church, K A Boudreaux, J N Lapin, Lauryn A Hahn, Leslie J Solis, Rachael Wilson, Henrik Zetterberg, Fernanda Catacci Guimaraes, Sam Shen and 6 more

Abstract readMulticenter Study
In one paragraph

Article in American journal of veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

LaTasha K CrawfordDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Molly E ChurchDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
K A BoudreauxOffice of Professional Education, School of Veterinary Medicine, University of California-Davis, Davis, CA.
J N LapinDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
Lauryn A HahnDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Leslie J SolisClinical and Translational Science Center, University of California-Davis, Davis, CA.
Rachael WilsonDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Henrik ZetterbergDepartment of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Fernanda Catacci GuimaraesVeterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA.
Sam ShenVeterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA.
Ryan G ToedebuschVeterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA.
Karen VernauVeterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA.ORCID https://orcid.org/0000-0002-8062-0028
Adrien DupanloupVeterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA.
Wojciech PanekDepartment of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
Starr CameronNeuroBiobank, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
Christine M ToedebuschVeterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA.ORCID https://orcid.org/0000-0002-3216-3344

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development ProgramK12CA138464 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BIRKELAND, ANDREW CHARLES, LARA, PRIMO N. · 2011 to 2025
$11.4M
Wisconsin Multidisciplinary K12 Urologic Research Career Development ProgramK12DK100022 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI CHAD M. VEZINA · 2013 to 2026
$8.6M
NCATS NIH HHS UL1 TR001860NCI NIH HHS K12 CA138464NIDDK NIH HHS K12 DK100022
6 · The paper itself

Abstract

Objective: To assess faculty interest in veterinary biospecimens, develop a standardized multi-institutional biological fluid repository across 3 veterinary institutions, and assess quality and fitness for purpose of archived samples. Methods: We conducted a prospective multi-institutional biobanking and feasibility study from 2022 through 2025. Faculty from each institution were administered a voluntary and anonymous survey via email, and responses were recorded. Biological fluid specimens were collected and archived from the Neurology and Neurosurgery Services of each participating institution. A shared database (Freezerworks) was utilized by all 3 institutions to annotate each sample with clinical data and record the storage location. Selected serum (n = 12), CSF (n = 12), and urine (n = 9) samples were assessed for quality control and fitness for purpose by measuring concentrations of putative biomarkers via ELISAs and single-molecule array, respectively. Results: Faculty surveys indicated widespread support for centralized institutional biobanking, with 94 of 170 respondents (55%) in favor of a combination of institutional and investigator financial support. Over 2,500 biological specimens from dogs and cats with neurological disease were collected during the 3-year study period. Sample quality across serum, urine, and CSF was consistent across institutions. Moreover, serum samples from randomly selected dogs with divergent diagnoses yielded robust and discriminatory concentrations of putative neurodegenerative disease proteins. Conclusions: Multi-institutional veterinary biobanking is feasible and productive, providing investigators with access to clinically annotated, high-quality biospecimens. Clinical Relevance: A common repository registry, wherein investigators have reciprocal access to standardized biospecimens, will connect investigators from all domains to promote rigorous, well-powered multicenter studies.

Indexed as

Biological Specimen BanksCat DiseasesDog DiseasesTranslational Research, BiomedicalAnimalsCatsDogsFeasibility StudiesProspective StudiesSurveys and QuestionnairesbiomarkersbiorepositoryClinical and Translational Science Awardfitness-for-purposeFreezerworks

Identifiers

PMID42114558
PMCPMC13472239

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.