Trial reportNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026
Modulation of evoked alpha oscillatory activity in the frontocentral region during analgesia by non-invasive brain stimulation.
Trial report in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Alpha oscillations in pain neuromodulation: From resting rhythms to reactive networks.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRepetitive transcranial magnetic stimulation (rTMS) to the posterior superior insula (PSI) can produce analgesia, although the underlying mechanisms require further exploration. While alpha oscillations have been implicated in rTMS-induced plasticity, research has largely focused on resting-state metrics, whereas alterations in perturbation-evoked alpha activity remain unknown.
objectiveTo examine the effect of PSI rTMS on perturbation-evoked alpha activity within a capsaicin-induced tonic pain model.
methodsTwenty healthy adults (10 females) completed two randomised, counterbalanced rTMS sessions (active, sham). Capsaicin was applied to the forearm for 90 min and pain intensity recorded at 5 min intervals on a numerical rating scale. Left PSI rTMS (10 Hz, 100 pulses/train, 15 trains) was delivered ∼50 min after capsaicin application. Evoked electroencephalographic responses to primary motor cortex (M1) TMS were assessed at baseline, during capsaicin-induced pain pre-rTMS, and post-rTMS. The frontocentral event-related spectral perturbation (ERSP) and parietal-occipital inter-trial coherence (ITC) were extracted.
resultsBaseline-normalised frontocentral ERSP showed a more positive pre-to-post change in M1-TMS-evoked alpha power following active rTMS relative to sham (p = 0.013), though no significant effect on ITC was observed. Exploratory analysis showed that lower pre-rTMS ITC predicted a greater reduction in pain with active rTMS (r = 0.68, p < 0.001).
conclusionsPSI-rTMS modulates evoked alpha oscillatory power in frontocentral regions, advancing our understanding of the mechanisms underlying rTMS-induced analgesia. Evoked frontocentral alpha power may index a change in pain state, whereas exploratory findings suggest that alpha-band parietal-occipital ITC may predict individual differences in the rTMS analgesic response, though larger studies are needed to confirm these findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.