ArticleMedicine2026
The role of anxiety, depression, and illness perception in quality of life of patients with rheumatoid arthritis: A structural equation model approach.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to construct and test a structural model of self-regulation for the relationship between health-related quality of life (HRQoL) and related factors in patients with rheumatoid arthritis. In this cross-sectional correlational study, 250 patients with rheumatoid arthritis who visited the outpatient clinic of a general hospital in Korea were selected through convenience sampling. Sociodemographic characteristics, clinical characteristics, HRQoL, awareness of disease outcomes, anxiety, depression, and stress coping strategies were evaluated using a questionnaire. Structural equation modeling was used to examine the proposed model. The final model for predicting HRQoL of patients had an explanatory power of 70.3% and demonstrated a good fit with the data. Anxiety, depression, and illness perception had direct negative effects on HRQoL. Self-efficacy and self-esteem showed indirect effects on HRQoL, fully mediated by illness perception. Social support, which was fully mediated by anxiety and depression, indirectly affected HRQoL. The self-regulation model tested in this study may serve as a framework for future intervention studies on improving HRQoL among patients.
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