ArticleClinical pharmacology and therapeutics2026
Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study.
Article in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5- to 1.8-fold. However, data from these in vivo studies are only available for some trimesters. Various endogenous metabolites (e.g., pyridoxic acid, glycochenodeoxycholate-3-sulfate (GCDCA-S)) have been identified as substrates of renal OAT1/3 and can potentially be utilized as phenotypic markers to study modulation of OAT1/3 activities across all trimesters of pregnancy. In this proof-of-concept study, we quantified the effect of late second to early third trimester (T2-T3) of pregnancy on the plasma concentration and renal clearance (CL
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