ArticlePsychological medicine2026
Commonalities in frailty and psychopathology predict chronotype across severe mental disorders from a comorbidity perspective.
Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIndividuals with severe mental illness (SMI) have increased risk of physical comorbidities, linked to worse outcomes such as greater psychopathology, frailty, and neurocognitive impairment. Mechanisms underlying this burden remain unclear. This study examined whether frailty and psychopathology predict evening chronotype, especially in SMI with comorbidities.
methodsA longitudinal study assessed 165 participants at two time points over one year: schizophrenia (
resultsNeurocognitive and functional impairments were greater in SMI groups than controls (
conclusionsPsychopathological and hematological profiles are associated with chronotype and may help identify subgroups for chronobiology-informed interventions. These findings support more personalized treatment approaches.
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