Evidence map›Paper›PMID 42117145›Full record

Trial reportJournal of Korean medical science2026

Limited Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Appetite and Body Weight: Evidence From Clinical and Rodent Studies.

Joonyub Lee, Sohee Park, Evonne Kim, Ji-Yeon Park, Marie Rhee, Jing W Hughes, Seung-Hyun Ko, Obin Kwon, Eun Young Lee

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joonyub Lee *Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-0533-9786
Sohee Park *Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8270-0681
Evonne Kim *Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-6312-4014
Ji-Yeon ParkDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-6824-8753
Marie RheeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-9507-902X
Jing W HughesSection of Endocrinology, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-4397-8175
Seung-Hyun KoDivision of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-3703-1479
Obin KwonDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3702-7202
Eun Young LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. leyme@catholic.ac.kr.ORCID https://orcid.org/0000-0002-4968-5026

Funding

Korea Health Industry Development Institute RS-2024-00403047Korea Health Industry Development Institute RS-2024-00404132Korean Diabetes Association 2016F-3National Research Foundation of Korea 2021R1C1C1013016
6 · The paper itself

Abstract

backgroundThe effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors on appetite and food intake remains unclear. This study investigated the effects of SGLT2 inhibitors on appetite, food craving, and body weight in patients with type 2 diabetes and diabetic rat models.

methodsThirty-four participants were randomized to receive either dapagliflozin or sitagliptin for 24 weeks. The primary endpoint was body weight changes from baseline; secondary outcomes included food intake, appetite and related hormone changes, and glycemic control. For rodent study, Otsuka Long-Evans Tokushima Fatty (OLETF) rats treated with empagliflozin for 12 weeks to evaluate chronic effect on food intake and appetite-related gene expression.

resultsWeight reduction in the dapagliflozin group was lower than expected, with a 1.99 kg difference at 24 weeks (

conclusionSustained SGLT2 inhibitor treatment does not cause compensatory appetite increase after weight stabilization. Furthermore, it does not stimulate appetite or affect appetite-regulating molecules, thereby supporting its metabolic safety with respect to energy intake. This finding suggests that less-than-expected weight loss with SGLT2 inhibitors may result from mechanisms other than sustained changes in appetite or food intake.

trial registrationClinical Research Information Service Identifier: KCT0009925.

Indexed as

AppetiteBenzhydryl CompoundsBody WeightDiabetes Mellitus, Type 2GlucosidesHypoglycemic AgentsSitagliptin PhosphateSodium-Glucose Transporter 2 InhibitorsAgedAnimalsBlood GlucoseDisease Models, AnimalEatingFemaleHumansLeptinBenzhydryl CompoundsBlood GlucosedapagliflozinempagliflozinGlucosidesHypoglycemic AgentsLeptinSitagliptin PhosphateSodium-Glucose Transporter 2Sodium-Glucose Transporter 2 InhibitorsAppetiteDiabetes Mellitus, Type 2Sodium-Glucose Transporter 2 InhibitorsWeight Loss

Identifiers

PMID42117145
PMCPMC13160830

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.