In one paragraphArticle in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Adriana Quijada-FreireChemokine Signaling group, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.
Blanca Soler PalaciosChemokine Signaling group, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.
Rosa Ayala-BuenoChemokine Signaling group, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.
Sofia R GardetaChemokine Signaling group, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.
Enara San SebastianDepartamento de Biología Molecular y Celular, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.
Maria Carmen PuertasIrsiCaixa, Badalona, Spain.
Luis Ignacio González-Granado12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Jose Miguel Rodriguez FradeChemokine Signaling group, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Madrid, Spain.
Jakub ChojnackiIrsiCaixa, Badalona, Spain.
Funding
Centro de Investigación Biotecnológica en Red de Enfermedades Infecciosas CB21/13/00063Centro Nacional de Biotecnología SEV-2017-0712Federación Española de Enfermedades Raras FIS PI21/01642Fundación para el Conocimiento Madri+d CAM20_CNB_AI_07Spanish National Plan for Scientific and Technical Research and Innovation PID2020-114980RB-I00Spanish National Plan for Scientific and Technical Research and Innovation PID2022-139271OB-I00Spanish National Plan for Scientific and Technical Research and Innovation PID2022-140651NB-I00Spanish National Plan for Scientific and Technical Research and Innovation PID2023-146301OB-I00Spanish National Plan for Scientific and Technical Research and Innovation PRE2018-083201Spanish National Plan for Scientific and Technical Research and Innovation PRE2019-087966Spanish National Plan for Scientific and Technical Research and Innovation PRE2022-000847
6 · The paper itselfAbstract
HIV-1 entry into susceptible cells requires the dynamic interaction of its envelope (Env) glycoprotein with the host cell receptor CD4 and a co-receptor, either CCR5 or CXCR4. While the core molecular mechanisms driving Env-receptor interactions and subsequent membrane fusion are well characterized, the precise nanoscale spatial reorganization of these co-receptors at the viral binding site remains poorly defined. In this study, we employed single-particle tracking total internal reflection fluorescence (SPT-TIRF) microscopy to quantitatively analyze nanoscale organizational changes of CXCR4 on the surface of human CD4
Indexed as
CD4-Positive T-LymphocytesCell MembraneHIV-1HIV Envelope Protein gp120HIV Envelope Protein gp41Receptors, CXCR4HumansMicroscopy, FluorescenceProtein MultimerizationVirus InternalizationCXCR4 protein, humangp120 protein, Human immunodeficiency virus 1HIV Envelope Protein gp120HIV Envelope Protein gp41Receptors, CXCR4CXCR4HIV-1humanimmunologyinfectioninflammationreceptor conformationsviruses
Identifiers
PMID42118136
PMCPMC13167113
What Socratic holds
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LicenceCC BY
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