Evidence map›Paper›PMID 42118204›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

An Implantable Optogenetics-Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light-Controlled Metabolic Reprogramming of Synovial Macrophages.

Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dahai HuDepartment of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, School of Medicine, Jinan University, Guangzhou, P. R. China.
Yaru SunDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, Guangdong, P. R. China.
Qi LuDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, Guangdong, P. R. China.
Yi ZhangDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, Guangdong, P. R. China.
Jieruo LiDepartment of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, School of Medicine, Jinan University, Guangzhou, P. R. China.
Huige HouDepartment of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, School of Medicine, Jinan University, Guangzhou, P. R. China.
Huajun WangDepartment of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, School of Medicine, Jinan University, Guangzhou, P. R. China.
Hui TangThe Clinical Medicine Research Institute, The First Affiliated Hospital of Jinan University, Guangzhou, P. R. China.
Yunsong ZhangThe Department of Plastic and Reconstructive Surgery, The Affiliated Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, P. R. China.
Xiaofei ZhengDepartment of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, School of Medicine, Jinan University, Guangzhou, P. R. China.
Qingsong MeiDepartment of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, Guangdong, P. R. China.ORCID https://orcid.org/0000-0003-4327-6931

Funding

Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University, China JNU1AF-CFTP-2022-a01204Guangdong Basic and Applied Basic Research Foundation 2023B1515020056Guangdong Provincial Science and Technology Plan 2023A0505020008Guangzhou Science and Technology Project 2023B03J1228Guangzhou Science and Technology Project 2024A03J0971Guangzhou Science and Technology Project 2024A04J6269Medical Joint Fund of Jinan University YXJC2024002National Natural Science Foundation of China 22074028National Natural Science Foundation of China 82172440National Natural Science Foundation of China 82572762National Natural Science Foundation of China T2422011Research Fund Program of Guangdong Provincial Key Laboratory of Speed Capability Research 2023B1212010009Shenzhen Medical Research Fund B2402007
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) has always been a therapeutic challenge in clinical due to the lack of effective drug treatments. Inspired by the impact of daily diet on RA, herein we proposed an innovative energy metabolism modulation strategy to reprogram synovial macrophages for RA treatment. An implantable hydrogel, encapsulating with optogenetics-engineered cells, was designed to enable in-situ and on-demand secretion of glucagon-like peptide-1 (GLP-1) through blue light irradiation. GLP-1 in synovium was found to activate GLP-1R/HK2/VDAC1 pathway to upregulate the tricarboxylic acid cycle and oxidative phosphorylation in macrophages. This metabolic reprogramming elicited a phenotypic transition in macrophage polarization, shifting from M0/M1 state to M2 state. Significantly, the GLP-1-mediated approach reduced synovial inflammatory cytokine levels and facilitated tissue repair and bone erosion recovery. These findings reveal the therapeutic potential of GLP-1R/HK2/VDAC1 pathway as a novel target for RA.

Indexed as

Arthritis, RheumatoidHydrogelsMacrophagesOptogeneticsSynovial MembraneAnimalsGlucagon-Like Peptide 1HumansMetabolic ReprogrammingMiceGlucagon-Like Peptide 1Hydrogelscartilage damagejoint inflammationmacrophage polarizationmetabolic reprogramming

Identifiers

PMID42118204
PMCPMC13336046

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.