ArticleAbdominal radiology (New York)2026
Dual-energy CT-derived multiparameters for noninvasive prediction of vessels encapsulating tumor clusters and microvascular invasion in hepatocellular carcinoma.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveVessels encapsulating tumor clusters (VETC) and microvascular invasion (MVI) are risk factors for early recurrence after hepatectomy in patients with hepatocellular carcinoma (HCC). This study aimed to assess the performance of multiparameters of dual-phase contrast-enhanced dual-energy CT (DECT) in identifying VETC and MVI statuses noninvasively.
methodsThis retrospective study enrolled 122 patients with pathologically confirmed HCC (VETC +/-, N = 57/65; MVI +/-, N = 54/68) who underwent contrast-enhanced DECT examinations. Conventional clinical information and radiological features were collected. DECT-derived multiparameters in the arterial phase (AP) and portal venous phase (PVP) were analyzed, including non-normalized effective atomic number (Zeff), electron density (ED), and iodine density (ID), and their corresponding normalized parameters (N1-2 Zeff, N1-2 ED, N1-2 ID) based on two normalization approaches (N1 = tumor-to-aorta ratio; N2 = tumor-to-liver parenchyma). The slope of the energy spectrum curve (λ) was also evaluated. Univariate and multivariate logistic regression analyses were performed to construct nomograms and conventional models. The performance of each parameter, conventional model, and nomogram for assessing VETC and MVI was assessed using the area under the receiver operating characteristic curve (AUC).
resultsMultiparameters predicted VETC and MVI with AUCs ranging from 0.64 to 0.77 (all p < 0.01). Compared with their non-normalized counterparts, the performances of N1-Zeff
conclusionDECT-derived multiparameters can be used to noninvasively identify VETC and MVI statuses. Nomograms incorporating these parameters enhance VETC and MVI prediction in HCC.
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