Evidence map›Paper›PMID 42118283›Full record

ArticleMikrochimica acta2026

Fluorescence/surface-enhanced Raman scattering dual-mode sensor based on Ag/CQDs/ZIF-8 for human carboxylesterase 1 detection.

Ziyu Xu, Jinru Cao, Ying Wang, Tingsha Chen, Yue Wang, Huaqiu Xu, Huihui Zeng, Wenyi Huang, Hao Cheng, Hongxing Kong and 2 more

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ziyu Xu *Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Jinru Cao *Dongguan Key Laboratory of Precision Molecular Diagnostics, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Guangdong, Dongguan, 523200, PR China.
Ying WangGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Tingsha ChenGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Yue WangGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Huaqiu XuGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Huihui ZengGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Wenyi HuangGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Hao ChengGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China.
Hongxing KongGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China. khx100@sina.com.
Yao LuGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China. luyao@gxust.edu.cn.
Jun FengGuangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, PR China. hxpfengjun@gxust.edu.cn.

Funding

National Natural Science Foundation of China 82460704, 82260701Natural Science Foundation of Guangxi Province 2020GXNSFAA297168
6 · The paper itself

Abstract

Human carboxylesterase 1 (hCE1) is a serine hydrolase that is distributed widely in the human liver, intestines, and various tumour tissues. It has now become a biomarker associated with diseases such as cancer. Consequently, the measurement of hCE1 levels in human serum is of significant importance for the diagnosis and assessment of these diseases. The present study involved the preparation of Ag/CQDs/ZIF-8 nanocomposites, which incorporated silver nanoparticles (Ag NPs) and carbon quantum dots (CQDs) into the ZIF-8 framework. The combination of this composite with an enzyme-linked immunosorbent assay (ELISA) and the utilisation of benzidine as the signal molecule resulted in the development of a fluorescence (FL)/surface-enhanced Raman scattering (SERS) dual-mode sensor, which was employed for the sensitive detection of hCE1 in serum. This dual-mode sensor combines the advantages of both FL and SERS technologies, demonstrating excellent selectivity and stability, and enhancing the accuracy and reliability of quantitative measurements. The limits of detection (LOD) for the FL mode and SERS mode were determined to be 0.1 and 0.072 ng·mL

Indexed as

Carboxylic Ester HydrolasesSpectrum Analysis, RamanCarbon Quantum DotsFluorescenceHumansLimit of DetectionMetal NanoparticlesSilverSpectrometry, FluorescenceCarboxylic Ester HydrolasesCES1 protein, humanSilverAg/CQDs/ZIF-8Dual-mode sensorFluorescence (FL)Human carboxylesterase 1 (hCE1)Surface-enhanced Raman scattering (SERS)

Identifiers

PMID42118283

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.