Evidence map›Paper›PMID 42118421›Full record

ReviewPurinergic signalling2026

The long march towards testing the adenosine receptor agonism hypothesis for human cerebroprotection: The story of the A

Theodore E Liston, William S Korinek, Kenneth A Jacobson, James D Lechleiter

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Purinergic signalling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Special issue of Medicinal Chemistry Research in honor of Dr. Kenneth A. Jacobson.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Theodore E ListonAstrocyte Pharmaceuticals Inc., 93 Shennecossett Road, Groton, CT, 06340, USA. liston@astrocytepharma.com.
William S KorinekAstrocyte Pharmaceuticals Inc., 93 Shennecossett Road, Groton, CT, 06340, USA.
Kenneth A JacobsonNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, 20892, USA.
James D LechleiterUniversity of Texas Health San Antonio, San Antonio, TX, 78229, USA.

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Correction of Mucopolysaccharidosis type 1: Targeting safe harbor loci using genome editingK08NS102398 · NINDS · STANFORD UNIVERSITY · PI GOMEZ-OSPINA, NATALIA · 2017 to 2022
$1.0M
Intramural NIH HHS ZIA DK031117Medical Technology Enterprise Consortium W81XWH-21-9-0001NIDDK NIH HHS ZIADK031117NINDS NIH HHS K08 NS102398NINDS NIH HHS R41NS094327NINDS NIH HHS R44NS102398
6 · The paper itself

Abstract

AST-004 is an adenosine A

Indexed as

Adenosine A1 Receptor AgonistsAdenosine A3 Receptor AgonistsNeuroprotective AgentsAnimalsHumansAdenosine A1 Receptor AgonistsAdenosine A3 Receptor AgonistsNeuroprotective AgentsAdenosine receptorAstrocytesConcussionIschemic strokeTraumatic brain injury

Identifiers

PMID42118421
PMCPMC13168404

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.