ReviewRheumatology (Oxford, England)2026
Targeting fibroblasts in immune mediated inflammatory diseases: a cellular basis for cure?
Review in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibroblasts constitute a major component of our stroma, the supportive bedding in which our tissues reside. The introduction of advanced single-cell technologies has greatly enhanced our appreciation of fibroblast heterogeneity in health and immune-mediated inflammatory diseases (IMIDs). This heterogeneity correlates with their diverse functions, including providing architectural support, tissue identity, 'stromal memory', and regulating immune responses and fibrosis. In RA, fibroblasts contribute to both synovial inflammation and bone and cartilage damage, and in IBD to loss of the epithelial barrier, intestinal inflammation, and the development of intestinal strictures and fistulae in Crohn's disease. Fibroblasts have also been associated with non-response to current biologic therapies in RA and IBD. Targeting pathogenic fibroblast populations using new therapeutic modalities such as Chimeric Antigen Receptor (CAR) T-cell therapies may 'reset' the stroma back to health and give hope for cure in these debilitating IMIDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.