Evidence map›Paper›PMID 42120750›Full record

ArticleCommunications biology2026

Genes, other than Muc5b, are associated with bleomycin-induced lung injury.

Yingping Wang, Corinne Hennessy, Evgenia Dobrinskikh, Stephen M Humphries, Kristina Hatakka, Cheryl L Ackert-Bicknell, Dana A Godfrey, Samir N P Kelada, Gregory R Keele, Jonathan Cardwell and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yingping WangDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-8468-8054
Corinne HennessyDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Evgenia DobrinskikhPerinatal Research Center, Children's Hospital Colorado Anschutz Medical Campus, Aurora, CO, USA.
Stephen M HumphriesDepartment of Radiology, National Jewish Health, Denver, CO, USA.
Kristina HatakkaDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cheryl L Ackert-BicknellDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-4253-4775
Dana A GodfreyColorado Program for Musculoskeletal Research, Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Samir N P KeladaDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-2676-9232
Gregory R KeeleRTI International, Research Triangle Park, Durham, NC, USA.ORCID http://orcid.org/0000-0002-1843-7900
Jonathan CardwellDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Anna PeljtoDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-8389-0736
David E ClouthierDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-2008-477X
Ivana V YangDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
David A SchwartzDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. david.schwartz@cuanschutz.edu.ORCID http://orcid.org/0000-0001-6743-8443

Funding

Genes and Transcripts that Interact with MUC5B in Pulmonary FibrosisR01HL149836 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CLOUTHIER, DAVID E., SCHWARTZ, DAVID ALBERT · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL149836U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL149836
6 · The paper itself

Abstract

The MUC5B promoter variant rs35705950 is the dominant risk factor for the development of idiopathic pulmonary fibrosis (IPF), yet its low penetrance remains unexplained. All eight founder strains of the Diversity Outbred (DO) mouse population carry the risk allele at the orthologous site, yet exhibited variable bleomycin-induced MUC5B expression and fibrosis severity. Herein, using the DO bleomycin model, we find that the Muc5b locus regulates MUC5B expression at 3 weeks, and at 10 weeks, several quantitative trait loci (QTLs) are associated with radiologic features of lung fibrosis, such as parenchymal consolidations. Cross-species integrations with human IPF studies reveal heterogeneous epithelial patterns and variable correlation with MUC5B among orthologous QTL genes, and expression of novel proteins in pathognomonic lesions of IPF. This study establishes a radiomics-genetics resource generated from DO mice subjected to bleomycin-induced lung injury, enabling systematic dissection of genetically driven heterogeneity in addition to MUC5B in lung imaging traits.

Indexed as

BleomycinIdiopathic Pulmonary FibrosisLung InjuryMucin-5BAnimalsDisease Models, AnimalGenetic Predisposition to DiseaseHumansLungMaleMiceQuantitative Trait LociBleomycinMuc5b protein, mouseMucin-5B

Identifiers

PMID42120750
PMCPMC13392033

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.