Trial reportBMC cardiovascular disorders2026
Sedentary behavior with atrial fibrillation-related biomarkers in overweight or obese adults.
Trial report in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBlood biomarkers can characterize the atrial substrate and help elucidate mechanisms of atrial fibrillation (AF) development. Understanding whether sedentary behavior affects AF-related biomarkers may inform prevention strategies.
methodsWe studied 252 participants in PREDIMED-Plus, a multicenter randomized trial in Spain for the primary prevention of cardiovascular disease. Participants wore wrist accelerometers for one week at baseline and at least once during follow-up (years 3 or 5). Blood samples were collected at each time point to measure selected biomarkers: propeptide of procollagen type I, high-sensitivity (hs) troponin T (hsTnT), hs C-reactive protein, 3-nitrotyrosine, and N-terminal propeptide of B-type natriuretic peptide (NT-proBNP). Using isotemporal substitution, we estimated the effect of replacing 30 min/day of sedentary time (< 1.5 METs in waking time) with low-intensity physical activity (LPA, 1.5-3 METs), moderate-to-vigorous PA (MVPA, > 3 METs), or time in bed (bedtime to wake-up) on log-transformed biomarker levels, cross-sectionally and longitudinally, via linear regression and mixed models.
resultsAt baseline, participants (mean age 65 ± 4.9 years, BMI 32.2 ± 3.3 kg/m², 40% women) showed no significant cross-sectional associations between substituting sedentary time and biomarker levels. After 5 years, replacing baseline 30-min of sedentary time per day with LPA or MVPA was associated with lower hs-TnT concentrations compared to baseline (-4%, 95% CI -8%, -1%; and - 2%, 95% CI -7%, 4%). Substitutions showed nonsignificant reductions in NT-proBNP but no consistent associations with other biomarkers.
conclusionsAmong overweight/obese individuals, replacing sedentary time with PA was associated with favorable 5-year changes of hs-TnT, but not other AF-related biomarkers.
trial registrationThe trial was registered on July 24, 2014, at ISRCTN (ISRCTN89898870) [ www.isrctn.com/ISRCTN89898870 (accessed on December 10, 2025)].
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