Evidence map›Paper›PMID 42121885›Full record

ReviewCells2026

The Multifaceted Role of microRNA-10b (miR-10b) in Glioblastoma: From Oncogenic Driver to Therapeutic Target.

Ming Chen, Zdravka Medarova, Lisa R Rogers, Anna Moore

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ming ChenPrecision Health Program, Michigan State University, 766 Service Road, East Lansing, MI 48824, USA.ORCID 0000-0002-5773-9848
Zdravka MedarovaTransCode Therapeutics, Inc., 400 Trade Center, Suite 5900, Woburn, MA 01801, USA.
Lisa R RogersDepartment of Surgery, College of Human Medicine, Michigan State University, 4660 S. Hagadorn Rd., East Lansing, MI 48823, USA.
Anna MoorePrecision Health Program, Michigan State University, 766 Service Road, East Lansing, MI 48824, USA.ORCID 0000-0002-5218-7204

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) remains one of the most lethal and treatment-resistant human malignancies, characterized by extreme molecular heterogeneity and a highly immunosuppressive tumor microenvironment (TME). MicroRNAs are a set of small endogenous non-coding RNA molecules which play critical roles in various biological processes including carcinogenesis. Recent evidence identifies microRNA-10b (miR-10b) as a regulator of gliomagenesis, with glioblastoma exhibiting a unique state of "oncogene addiction" to this molecule. This review summarizes current research on the mechanistic roles of miR-10b in GBM tumor progression and immune evasion, evaluates innovative antisense oligonucleotide delivery systems, and explores the clinical potential of combining miR-10b inhibition with standard-of-care treatments.

Indexed as

Brain NeoplasmsGlioblastomaMicroRNAsOncogenesAnimalsCarcinogenesisGene Expression Regulation, NeoplasticHumansOligonucleotides, AntisenseTumor MicroenvironmentMicroRNAsMIRN10 microRNA, humanOligonucleotides, Antisensecombination therapyglioblastomamicroRNA-10boligonucleotide drug delivery

Identifiers

PMID42121885
PMCPMC13162867

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.