Evidence map›Paper›PMID 42121940›Full record

ReviewCells2026

Limitations of Stem Cell Therapy for Parkinson's Disease.

Zhuowei Li, Shijun Peng, Jia Ouyang, Ruen Liu

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhuowei LiPeking University First School of Clinical Medicine, Peking University Health Science Center, Beijing 100191, China.
Shijun PengDepartment of Neurosurgery, Peking University People's Hospital, Beijing 100044, China.
Jia OuyangDepartment of Neurosurgery, Peking University People's Hospital, Beijing 100044, China.ORCID 0000-0002-7601-5773
Ruen LiuDepartment of Neurosurgery, Peking University People's Hospital, Beijing 100044, China.

Funding

the National Key Research and Development Program of China 2019YFE0117100the National Natural Science Foundation of China 82104603
6 · The paper itself

Abstract

Stem cell therapy, as a potential treatment for Parkinson's disease (PD), has been investigated in many clinical trials for its effectiveness. However, the therapeutic outcomes have shown considerable variability. This may be due to certain limitations of stem cell therapies, such as the inability to ameliorate non-motor symptoms or modify underlying disease mechanisms, and the limited applicability in certain patient populations. Combinations with the recently emerging gene therapy and other available technologies are expected to make up for or break down these limitations of stem cell therapy, thereby broadening its scope of application. In this review, we will discuss the limitations of stem cell therapy in terms of pathogenesis, symptoms, and population, as well as possible coping strategies to enhance the effectiveness of stem cell therapy.

Indexed as

Cell- and Tissue-Based TherapyParkinson DiseaseStem CellsStem Cell TransplantationAnimalsGenetic TherapyHumansgene therapyParkinson’s diseasestem cell therapy

Identifiers

PMID42121940
PMCPMC13162666

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.