Evidence map›Paper›PMID 42123315›Full record

ArticleInternational journal of molecular sciences2026

A Twin Study on the Relation Between Positive Mental Health and Biological Aging.

Corrado Fagnani, Angelo Picardi, Emanuela Medda, Miriam Salemi, Cristina D'Ippolito, Ester Siniscalchi, Francesca Salani, Giorgia M Varalda, Francesca Marcon

Abstract readTwin Study
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Corrado FagnaniCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0001-5771-7772
Angelo PicardiCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Emanuela MeddaCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-4837-4549
Miriam SalemiCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-0212-5515
Cristina D'IppolitoCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Ester SiniscalchiUnit of Mechanisms/Biomarkers/Models, Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Francesca SalaniUnit of Mechanisms/Biomarkers/Models, Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Giorgia M VaraldaUnit of Mechanisms/Biomarkers/Models, Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Francesca MarconUnit of Mechanisms/Biomarkers/Models, Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-0431-8310

Funding

Istituto Superiore di Sanità ISS20-05a136ecda0b
6 · The paper itself

Abstract

Positive mental health (PMH) has recently become a key topic in biomedical research. Previous studies have explored the correlation between biological and psychological measures, but only a few have focused on the relationship between PMH and aging. This study aimed: (i) to explore the association between PMH and biological aging; (ii) to determine if and to what extent the observed association could be explained by shared genetic and environmental effects. A total of 401 twins (age 19-81 years, 32% male) from the Italian Twin Registry were recruited, and the twin study design was applied. A self-report psychological test battery was used to evaluate several PMH components. Blood samples were collected from participants to determine telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). TL was negatively associated with attachment anxiety (r = -0.11,

Indexed as

AgingMental HealthAdultAgedAged, 80 and overAnxietyCross-Sectional StudiesDNA Copy Number VariationsDNA, MitochondrialFemaleHumansMaleMiddle AgedYoung AdultDNA, Mitochondrialagingmental healthtwins

Identifiers

PMID42123315
PMCPMC13164265

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.