Isomer-Dependent Pharmacokinetic Behavior and VKOR Interactions of Second-Generation Anticoagulant Rodenticides: An Integrated In Vivo-In Vitro-In Silico Investigation.

Moyu Miyamae, Satoru Nagaoka, Teppei Hayama, Misaki Fukamatsu, Ryo Kamata, Kazuki Takeda

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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5 · Who and what money

Authors and funding

6 authors.

Moyu MiyamaeLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, Towada 034-0021, Japan.

Satoru NagaokaDaimaru Compound Chemical Co., Ltd., Nagano 381-1222, Japan.

Teppei HayamaLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, Towada 034-0021, Japan.

Misaki FukamatsuLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, Towada 034-0021, Japan.

Ryo KamataLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, Towada 034-0021, Japan.ORCID 0000-0003-4086-3938

Kazuki TakedaLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, Towada 034-0021, Japan.ORCID 0000-0002-3265-4143

Funding

Environment Research and Technology Development Fund JPMEERF20254001JST BOOST Program Japan JPMJBY24E6Sasakawa Scientific Research Grant from The Japan Science Society 2025-4032

6 · The paper itself

Abstract

Second-generation anticoagulant rodenticides (SGARs) were developed to overcome warfarin resistance in rodent populations; however, their prolonged hepatic retention has raised concerns regarding secondary poisoning of non-target wildlife. All major SGARs exist as cis-trans isomeric pairs, and differences in biological half-life between isomers have been reported, yet the molecular basis for such isomer-dependent pharmacokinetic behavior remains poorly understood. In this study, we conducted an integrated evaluation of cis and trans isomers of SGARs using in vivo, in vitro, and in silico approaches, with vitamin K epoxide reductase (VKOR) serving as the molecular target. The individual compounds exhibited distinct isomer-dependent profiles in hepatic retention, inhibitory potency (IC

Indexed as

AnticoagulantsRodenticidesVitamin K Epoxide Reductases4-HydroxycoumarinsAnimalsComputer SimulationIsomerismMolecular Docking SimulationMolecular Dynamics Simulation4-HydroxycoumarinsAnticoagulantsbromadioloneflocoumafenRodenticidesVitamin K Epoxide Reductasescis–trans isomersmolecular dockingmolecular dynamicsprotein–ligand interactionsecond-generation anticoagulant rodenticidesvitamin K epoxide reductase

Identifiers

PMID42123380

DOI10.3390/ijms27093794

PMCPMC13164442

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.