Evidence map›Paper›PMID 42123438›Full record

ArticleInternational journal of molecular sciences2026

TLR2 Activation Enhances Inflammatory Signaling and Accelerates Cyst Growth and Renal Fibrosis in Polycystic Kidney Disease Mice.

Aiping Wei, Yang Zhang, Yu Xu, Jaden Schneider, Nicholas Detterman, Xiaoyun Shu, Tyler Gregersen, Maximo Nahas Folch, Yong Li, Shibiao Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aiping WeiDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Yang ZhangDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Yu XuDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Jaden SchneiderDepartment of Biological Science, College of Sciences and Arts, Michigan Technological University, Houghton, MI 49931, USA.ORCID 0009-0006-3272-6166
Nicholas DettermanDepartment of Biological Science, College of Sciences and Arts, Michigan Technological University, Houghton, MI 49931, USA.
Xiaoyun ShuDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Tyler GregersenDepartment of Biological Science, College of Sciences and Arts, Michigan Technological University, Houghton, MI 49931, USA.ORCID 0009-0003-5946-6999
Maximo Nahas FolchDepartment of Biological Science, College of Sciences and Arts, Michigan Technological University, Houghton, MI 49931, USA.
Yong LiDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.ORCID 0000-0002-4108-0989
Shibiao ChenDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.
Yan ZhangDepartment of Biological Science, College of Sciences and Arts, Michigan Technological University, Houghton, MI 49931, USA.

Funding

High Urinary Phosphate Induces TLR4-mediated Inflammation and Cystogenesis in Polycystic Kidney DiseaseR15DK137195 · NIDDK · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ZHANG, YAN · 2023 to 2023
$470k
NIDDK NIH HHS R15 DK137195NIDDK NIH HHS R15DK137195The PKD Foundation 1021264
6 · The paper itself

Abstract

Polycystic kidney disease (PKD), the most common inherited kidney disorder, is characterized by progressive cyst growth and eventual organ failure. Although aberrant innate immune activation is a recognized contributor to PKD progression, the underlying molecular mechanisms remain incompletely defined. Here, we showed that

Indexed as

InflammationPolycystic Kidney DiseasesSignal TransductionToll-Like Receptor 2AnimalsCell ProliferationDisease Models, AnimalFibrosisHumansKidneyLipopeptidesMaleMiceMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88LipopeptidesMyeloid Differentiation Factor 88NF-kappa BPam(3)CSK(4) peptideTlr2 protein, mouseToll-Like Receptor 2Toll-Like Receptor AgonistsTOR Serine-Threonine KinasesTRPP Cation ChannelsDAMPsinnate immunitymacrophageNF-κB

Identifiers

PMID42123438
PMCPMC13164350

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.