ArticleInternational journal of molecular sciences2026
Genome-Wide CRISPR Screening Identifies Genetic Modulators of Amyloid Precursor Protein Processing.
You Li, Yingjia Yao, Zitao Xu, Yufei Xiong, Cheng Zhang, Li Yu, Huiling Gao, Teng Fei
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
You LiInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.ORCID 0000-0002-3325-0730 Yingjia YaoInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.
Zitao XuInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.
Yufei XiongInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.
Cheng ZhangInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.ORCID 0009-0007-9156-9778 Li YuInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.
Huiling GaoInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.
Teng FeiInterdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China.ORCID 0000-0001-9620-0450 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The proteolytic processing of the amyloid precursor protein (APP) is a core pathological event in Alzheimer's disease (AD) pathogenesis, yet the global genetic regulatory networks modulating this process have not been fully characterized. To systematically identify novel regulators of APP cleavage, we performed a genome-wide CRISPR/Cas9 knockout screen utilizing an optimized UAS-GAL4-based cellular reporter, and identified genetic modulators governing amyloidogenic and non-amyloidogenic processing. The screen uncovered distinct functional gene clusters regulating the APP, prominently involving cellular metabolism, protein modification, and vesicular trafficking. Specifically,
Indexed as
Alzheimer DiseaseAmyloid beta-Protein PrecursorCRISPR-Cas SystemsProtein Processing, Post-TranslationalAmyloid beta-PeptidesHumansAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAlzheimer’s diseaseamyloid precursor proteinAPP processingcellular metabolismCRISPR screenLDHBPIAS2post-translational modification
Identifiers
PMID42123509
PMCPMC13163791
What Socratic holds
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