Evidence map›Paper›PMID 42123607›Full record

ReviewInternational journal of molecular sciences2026

Sulforaphane-Activated Functional Nucleic Acids for Cancer Therapy: Mechanisms, Delivery Strategies, and Nanomedicine Advances.

Mukesh Kumar, Nasir A Ibrahim, Shafiq Ur Rahman, Kevaun Altamon George Wilson, Salwa Eman, Nosiba S Basher, Walid Elfalleh, Mohamed Osman Abdalrahem Essa, Ahmed A Saleh, Hosameldeen Mohamed Husien and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mukesh KumarCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Nasir A IbrahimDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.ORCID 0000-0001-6382-8807
Shafiq Ur RahmanCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Kevaun Altamon George WilsonCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Salwa EmanCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Nosiba S BasherDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.ORCID 0000-0001-8814-5957
Walid ElfallehDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.ORCID 0000-0002-3493-6451
Mohamed Osman Abdalrahem EssaCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Ahmed A SalehCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-1314-8066
Hosameldeen Mohamed HusienCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.ORCID 0009-0008-8993-3507
Mengzhi WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Xiaodong GuoCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.

Funding

This work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) (grant number IMSIU-DDRSP2602)
6 · The paper itself

Abstract

Cancer therapy is increasingly shaped by the need for agents that are both mechanistically precise and clinically tolerable. Sulforaphane (SFN), a dietary isothiocyanate enriched in cabbage-family vegetables such as cauliflower and Brussels sprouts, has emerged as a pleiotropic modulator of tumor biology. This review synthesizes current evidence that SFN regulates diverse cancer-relevant processes, including redox homeostasis, cell-cycle progression, apoptosis, autophagy and epigenetic remodeling, largely through coordinated effects on transcriptional (for example, Nrf2, MAPK, NF-κB and AP-1), post-transcriptional (microRNAs and messenger RNAs) and epigenetic (DNA methyltransferases and histone deacetylases) networks. We then examine how functional nucleic acids, including aptamers, small interfering RNAs, microRNAs and tetrahedral

Indexed as

Anticarcinogenic AgentsIsothiocyanatesNanomedicineNeoplasmsNucleic AcidsSulfoxidesAnimalsDrug Delivery SystemsHumansRNA, Small InterferingAnticarcinogenic AgentsIsothiocyanatesNucleic AcidsRNA, Small InterferingsulforaphaneSulfoxidescancer therapychemopreventionFunctional Nucleic Acids (FNAs)SFN-based therapiesSulforaphane (SFN)targeted drug delivery

Identifiers

PMID42123607
PMCPMC13163298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.