Evidence map›Paper›PMID 42123771›Full record

ArticleMolecules (Basel, Switzerland)2026

Ex Vivo Characterization and In Vivo Nasal Delivery of Ropinirole-Loaded PEO-b-PCL/Tween 80/β-Cyclodextrin Systems in C57BL/6J Mice.

Elmina-Marina Saitani, Paraskevi Papakyriakopoulou, Evangelos Balafas, Dimitrios E Damalas, Nikolaos Kostomitsopoulos, Stergios Pispas, Natassa Pippa, Nikolaos Thomaidis, Georgia Valsami

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elmina-Marina SaitaniSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Paraskevi PapakyriakopoulouSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0003-0566-0713
Evangelos BalafasLaboratory Animal Facility, Centre of Clinical and Experimental Surgery and Translational Research, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.ORCID 0000-0003-0270-7088
Dimitrios E DamalasLaboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.ORCID 0000-0002-2997-7566
Nikolaos KostomitsopoulosLaboratory Animal Facility, Centre of Clinical and Experimental Surgery and Translational Research, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.ORCID 0000-0003-4787-5106
Stergios PispasTheoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.ORCID 0000-0002-5347-7430
Natassa PippaSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0002-1197-9010
Nikolaos ThomaidisLaboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.ORCID 0000-0002-4624-4735
Georgia ValsamiSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.ORCID 0000-0002-2395-6844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intranasal administration is a promising drug delivery route enabling precise and rapid central nervous system targeting. In our previous work, twelve hybrid colloidal dispersions were developed, consisting of synthetic poly(ethylene-oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) block copolymers with an increasing proportion of the hydrophobic PCL segment, Tween 80 (Tw80) and β-cyclodextrin derivatives (βCD), either methyl-β-CD (MβCD) or hydroxy-propyl-β-CD (HPβCD) for IN delivery of ropinirole hydrochloride (RH). Colloidal dispersions were prepared at different weight ratios (system/RH equal to 10:1 and 10:5), characterized and evaluated in vitro. The aim of this study is to evaluate the ex vivo permeation through rabbit nasal mucosa and determine the pharmacokinetic parameters of RH, when administered intranasally as a colloidal dispersion, compared with oral and intranasal RH solutions in C57BL/6J mice. Ex vivo permeation studies showed that all formulations significantly enhanced RH permeation compared to the pure RH solution (0.5 mg/mL, pH 5.6). Among them, F4 [(PEO-b-PCL

Indexed as

beta-CyclodextrinsDrug CarriersDrug Delivery SystemsIndolesPolyestersPolyethylene GlycolsAdministration, IntranasalAnimalsMaleMiceMice, Inbred C57BLNasal MucosaRabbitsbeta-CyclodextrinsDrug CarriersIndolesPolyestersPolyethylene GlycolsropiniroleCNS targetingcolloidal dispersionex vivo permeation studiesintranasal drug deliverypharmacokineticsropinirole hydrochloride

Identifiers

PMID42123771
PMCPMC13165381

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.