Evidence map›Paper›PMID 42123783›Full record

ArticleMolecules (Basel, Switzerland)2026

Development and Validation of a Quantitative LC-MS/MS Method for Measuring CYP4V2 Enzyme Activity via 12-Hydroxylauric Acid in rAAV-hCYP4V2 Gene Therapy Products.

Ge Ren, Xi Qin, Yiran Li, Wenhong Fan, Wenjing Luo, Yanrong Cao, Yang Wang, Yong Zhou, Chenggang Liang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ge RenNational Institutes for Food and Drug Control, Beijing 100050, China.ORCID 0009-0003-4482-8811
Xi QinNational Institutes for Food and Drug Control, Beijing 100050, China.
Yiran LiNational Institutes for Food and Drug Control, Beijing 100050, China.ORCID 0009-0009-1884-4440
Wenhong FanNational Institutes for Food and Drug Control, Beijing 100050, China.
Wenjing LuoShanghai Vitalgen BioPharma Co., Ltd., Shanghai 201210, China.
Yanrong CaoShanghai Vitalgen BioPharma Co., Ltd., Shanghai 201210, China.
Yang WangSchool of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China.
Yong ZhouNational Institutes for Food and Drug Control, Beijing 100050, China.
Chenggang LiangNational Institutes for Food and Drug Control, Beijing 100050, China.ORCID 0000-0001-8916-6872

Funding

Beijing Municipal Science and Technology Commission Z251100004625002the National Key R&D Program of China 2023YFC3403305
6 · The paper itself

Abstract

Bietti crystalline dystrophy (BCD) is a hereditary retinal disease caused by loss-of-function mutations in the

Indexed as

Cytochrome P450 Family 4DependovirusGenetic TherapyLauric AcidsLiquid Chromatography-Mass SpectrometryTandem Mass SpectrometryChromatography, LiquidCorneal Dystrophies, HereditaryGene Therapy AgentsHeLa CellsHumansReproducibility of ResultsRetinal DiseasesCYP4V2 protein, humanCytochrome P450 Family 4lauric acidLauric AcidsAAVCYP4V2enzyme activitygene therapylauric acid ω-hydroxylationLC-MS/MSmethod validation

Identifiers

PMID42123783
PMCPMC13165093

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.