Evidence map›Paper›PMID 42124459›Full record

ArticleChemistry & biodiversity2026

Natural Product Rengyolone Attenuates LPS-Induced Microglia Inflammation via Suppression of the TLR4/NF-κB Pathway.

Zhao-Ting Li, Qi-Chao Sun, Xue-Mei Yang, Xian-Peng Zu, Xin Chen, Xi-Ke Xu, Jing-Jin Wang, Xian Li, Yun-Heng Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhao-Ting LiSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.
Qi-Chao SunSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.
Xue-Mei YangSchool of Pharmacy, Dali University, Dali, China.
Xian-Peng ZuSchool of Pharmacy, Naval Medical University, Shanghai, China.
Xin ChenSchool of Pharmacy, Naval Medical University, Shanghai, China.
Xi-Ke XuSchool of Pharmacy, Naval Medical University, Shanghai, China.
Jing-Jin WangDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.
Xian LiSchool of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.
Yun-Heng ShenSchool of Pharmacy, Naval Medical University, Shanghai, China.

Funding

Key Project of Yunnan Province Applied Basic Research Program 202401AS070060
6 · The paper itself

Abstract

Rengyolone, a cyclohexylethanol derivative isolated from Incarvillea mairei (Bignoniaceae), exhibited a potent anti-inflammatory effect in LPS-stimulated BV-2 cells by inhibiting the release of the inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE

Indexed as

Anti-Inflammatory AgentsBiological ProductsInflammationMicrogliaNF-kappa BToll-Like Receptor 4AnimalsCell LineCyclooxygenase 2CytokinesDinoprostoneLipopolysaccharidesMiceNitric OxideNitric Oxide Synthase Type IISignal TransductionAnti-Inflammatory AgentsBiological ProductsCyclooxygenase 2CytokinesDinoprostoneLipopolysaccharidesNF-kappa BNitric OxideNitric Oxide Synthase Type IITlr4 protein, mouseToll-Like Receptor 4BV‐2 cellsinflammationnatural productrengyoloneTLR4/NF‐κB pathway

Identifiers

PMID42124459
PMCPMC13381006

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.