Evidence map›Paper›PMID 42124692›Full record

ArticlebioRxiv : the preprint server for biology2026

Early proteomic signatures of Alzheimer's disease in the retina and brain of 3xTg-AD mice.

Artjola Puja, Rachel McNeel, Rong Xu, Siyan Zhu, David Hansman, Jianhai Du

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Artjola PujaDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26505, USA.
Rachel McNeelDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26505, USA.
Rong XuDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26505, USA.
Siyan ZhuDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26505, USA.
David HansmanDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26505, USA.
Jianhai DuDepartment of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV 26505, USA.ORCID 0000-0002-2019-8128

Funding

Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
VS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Visvanathan Ramamurthy · 2022 to 2026
$13.9M
Human RPE metabolism and metabolite transportR01EY026030 · NEI · UNIVERSITY OF WASHINGTON · PI CHAO, JENNIFER RAYMING, DU, JIANHAI · 2016 to 2020
$2.1M
Retinal Mitochondrial Metabolism in Alzheimer's DiseaseR01EY031324 · NEI · WEST VIRGINIA UNIVERSITY · PI DU, JIANHAI · 2021 to 2024
$2.0M
Proline metabolism in retinal healthR01EY032462 · NEI · WEST VIRGINIA UNIVERSITY · PI DU, JIANHAI · 2021 to 2025
$1.9M
NEI NIH HHS R01 EY026030NEI NIH HHS R01 EY031324NEI NIH HHS R01 EY032462NIGMS NIH HHS P20 GM144230NIGMS NIH HHS R24 GM137786
6 · The paper itself

Abstract

Visual dysfunction and retinal structural alterations often precede brain pathology and cognitive decline in Alzheimer's disease (AD), yet the molecular basis of these early changes and their relationship to the brain pathology remain unclear. Here, we performed quantitative proteomic profiling of retina and brain from 1-month of age triple-transgenic (3xTg-AD) mice harboring human PS1

Indexed as

Alzheimer’s diseasebrainmitochondrianeurodegenerative disordersproteomicsretina

Identifiers

PMID42124692
PMCPMC13160029

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.