Evidence map›Paper›PMID 42126226›Full record

ArticlemBio2026

ThLaeA functions as a conditional repressor to maintain metabolic homeostasis in

Wei Li, Zili Song, Huan Liu, Huomiao Ran, Wenzhao Wang, Kuan Li, Nancy P Keller, Wen-Bing Yin

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei Li *State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0001-6639-0441
Zili Song *State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0001-5087-8290
Huan Liu *State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Huomiao RanState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Wenzhao WangState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Kuan LiState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, USA.ORCID 0000-0002-4386-9473
Wen-Bing YinState Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-9184-3198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global regulator LaeA is widely recognized as a master activator of secondary metabolism and development in filamentous fungi. Yet its role under genetically buffered or metabolically stable conditions-where canonical phenotypes are masked-remains poorly understood. This study aimed to characterize the LaeA ortholog ( IMPORTANCE: LaeA plays compelling roles in secondary metabolism and development in filamentous fungi. However, related research also found that genetic operations of LaeA have no obvious effect on the metabolic spectrum in some fungal species. Many attempts have been made to decipher the phenomenon and to explain how about the function of LaeA in these cases. Here, we identified a ThlaeA in

Indexed as

Fungal ProteinsGene Expression Regulation, FungalHomeostasisRepressor ProteinsTrichodermaGene DeletionGene Expression ProfilingGene Knockout TechniquesMetabolomicsOxidative StressSecondary MetabolismFungal ProteinsRepressor Proteinsfilamentous fungiLaeAmetabolomic–transcriptomic integrationregulatory networksecondary metabolism

Identifiers

PMID42126226
PMCPMC13251417

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.