Evidence map›Paper›PMID 42127195›Full record

ArticleScience advances2026

From hotspots to hotspaces: Cascaded photonic-plasmonic coupling for SERS-based deep profiling of whole small extracellular vesicles.

Haoming Bao, Emily Xi Tan, Jie Zhou, Xiang Zhao, Sheng Yuan Leong, Chang Hoong Chek, Guo Kang Leon, Jaslyn Ru Ting Chen, Lam Bang Thanh Nguyen, Ling Li and 4 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haoming BaoKey Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, P.R. China.ORCID 0000-0003-1071-1431
Emily Xi TanSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.ORCID 0000-0001-5643-974X
Jie ZhouDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P.R. China.
Xiang ZhaoDepartment of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, P.R. China.ORCID 0009-0009-3260-7986
Sheng Yuan LeongLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0009-0003-9952-1067
Chang Hoong ChekSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.ORCID 0009-0007-1862-067X
Guo Kang LeonSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Jaslyn Ru Ting ChenSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.ORCID 0009-0007-0425-0495
Lam Bang Thanh NguyenSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Ling LiSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.ORCID 0009-0005-2256-6333
Han Wei HouLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0001-6631-6321
Hongwen ZhangKey Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, P.R. China.ORCID 0000-0002-1358-7336
In Yee PhangKey Laboratory of Synthetic and Biological Colloids, Ministry of Education, International Joint Research Laboratory for Nano Energy Composites, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, P.R. China.ORCID 0000-0002-3362-2645
Xing Yi LingSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.ORCID 0000-0001-5495-6428

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spatial confinement of electromagnetic hotspots (<15 nanometers) in plasmonic nanostructures fundamentally restricts their utility for probing large, heterogeneous targets across diverse material and biological systems. We introduce a cascaded photonic-plasmonic strategy that bridges far-field illumination and near-field enhancement by integrating dielectric silicon dioxide microspheres that form subdiffraction nanojets on a plasmonic, gold-coated silicon dioxide nanoarray. This dual-layer architecture generates spatially extended electromagnetic "hotspaces" exceeding 110 nanometers in lateral extent and sustaining analytical enhancement factors > 10

Indexed as

Extracellular VesiclesPhotonsSpectrum Analysis, RamanGoldHumansMicrospheresNanostructuresSilicon DioxideSurface Plasmon ResonanceGoldSilicon Dioxide

Identifiers

PMID42127195
PMCPMC13170666

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.