Evidence map›Paper›PMID 42128485›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2026

Nocturnal hypercapnia in obstructive sleep apnoea and obesity hypoventilation: from pathophysiology to measurement and treatment.

Winfried J Randerath, Francesco Fanfulla, Jean Louis Pépin

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Beyond nocturnal hypercapnia: positioning obstructive sleep apnoea within a sleep-circadian-hypothalamic network.European respiratory review : an official journal of the European Respiratory Society · 2026
    Article
  2. The Sleep and Breathing Conference: a long-standing and unique ERS/ESRS educational activity.European respiratory review : an official journal of the European Respiratory Society · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Winfried J RanderathClinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Institute of Pneumology at the University of Cologne, Solingen, Germany randerath@klinik-bethanien.de.ORCID https://orcid.org/0000-0002-5010-8461
Francesco FanfullaSleep and Respiratory Function Unit of the Pavia and Montescano Institutes, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
Jean Louis PépinUniversité Grenoble Alpes, INSERM HP2 (U1300) and Grenoble University Hospital, Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breathing disturbances during sleep are associated with intermittent hypoxaemia, arousal and sympathetic activation, which in turn lead to oxidative stress and cardiovascular and metabolic consequences. However, they are also characterised by fluctuations of carbon dioxide levels, switching between hypercapnia and hypocapnia, which contribute to acute and sustained physiological and cellular effects. Changes in arterial carbon dioxide tension (

Indexed as

Carbon DioxideCircadian RhythmHypercapniaLungObesity Hypoventilation SyndromeSleepSleep Apnea, ObstructiveBiomarkersHumansPredictive Value of TestsRisk FactorsTime FactorsTreatment OutcomeBiomarkersCarbon Dioxide

Identifiers

PMID42128485
PMCPMC13169059

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.