Evidence map›Paper›PMID 42128904›Full record

Observational studyScientific reports2026

Chronic pain in a modern virally suppressed HIV cohort is associated with disability and poorer mental health.

Ronald J Ellis, Robert K Heaton, J Hampton Atkinson, Murray B Stein, Crystal Wang, Tyler R Bell, Andrew H Miller, David Grelotti, David Moore

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ronald J EllisDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA. roellis@health.ucsd.edu.
Robert K HeatonDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA.
J Hampton AtkinsonDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA.
Murray B SteinDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA.
Crystal WangDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA.
Tyler R BellDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA.
Andrew H MillerDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, 30322, USA.
David GrelottiDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA.
David MooreDepartment of Psychiatry, University of California San Diego, San Diego, CA, 92093, USA.

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
Chronic Pain and Risk of Alzheimer's-Related NeurodegenerationK01AG081559 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tyler Reed Bell · 2023 to 2026
$505k
NIA NIH HHS K01 AG081559NIA NIH HHS K01AG081559NIMH NIH HHS P30 MH062512NIMH NIH HHS P30MH062512
6 · The paper itself

Abstract

Chronic pain (CP) is common among people with HIV (PWH), yet its prevalence and associated factors in those receiving modern, virally suppressive antiretroviral therapy (ART) are not well understood. This prospective observational study compared CP frequency and associated outcomes between PWH and people without HIV (PWoH). Participants (40 PWH, 23 PWoH) completed a questionnaire assessing daily pain lasting more than three months. Additional data included pain intensity, interference with daily activities, opioid use, and depressed mood (Beck Depression Inventory-II), as well as HIV clinical markers and comorbidities. Groups were demographically similar; all PWH were virally suppressed, with a mean HIV duration of 27.0 years, median nadir CD4 count of 173 cells/μL, and median current CD4 count of 644 cells/μL. CP was significantly more frequent in PWH (60%) than in PWoH (22%; OR = 5.40, 95% CI [1.67, 17.50]; p = 0.003). Among PWH, CP was associated with greater daily activity interference, higher opioid use, and increased neuropathic pain symptoms. PWH with CP also had higher BDI-II scores, indicating worse mood. These findings suggest that CP remains prevalent and disabling among PWH despite effective modern-day ART, underscoring the need for targeted pain assessment and management in this population.

Indexed as

Chronic PainHIV InfectionsMental HealthPersons with DisabilitiesAdultDepressionFemaleHumansMaleMiddle AgedProspective StudiesChronic painDepressionMoodNeuropathic painOpioid use

Identifiers

PMID42128904
PMCPMC13365815

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.