Evidence map›Paper›PMID 42129178›Full record

ArticleNature communications2026

Selective and differential roles of PVH

Zhiying Jiang, Yuhan Cao, Michelle He, Cunjin Su, Runzhou Yang, Maojie Yang, Jing Cai, Hongli Li, Yuanzhong Xu, Shi-Bin Li and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhiying Jiang *The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Yuhan Cao *The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Michelle HeSummer Undergraduate Research Program, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Cunjin SuThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-3728-3377
Runzhou YangThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Maojie YangThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jing CaiThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-8448-8151
Hongli LiThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Yuanzhong XuThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5264-5324
Shi-Bin LiDepartment of Anesthesiology, Zhongshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-5699-3035
Hiroshi YamaguchiDivision of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, Okazaki, Japan.
Luis de LeceaDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8921-5942
Benjamin R ArenkielDepartment of Molecular and Human Genetics and Department of Neuroscience, Baylor College of Medicine, and Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9047-2420
Qingchun TongThe Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX, USA. Qingchun.Tong@uth.tmc.edu.ORCID http://orcid.org/0000-0002-4561-2540

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, NELSON, DAVID LOREN · 2014 to 2019
$7.8M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
Hypothalamic CRH Neurons in Diet-induced ObesityR01DK135212 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Qingchun Tong · 2023 to 2026
$2.1M
Neural pathways for obesity development by AgRP neuronsR01DK136284 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Qingchun Tong · 2023 to 2026
$1.8M
A novel MC4R neural pathway in feedingR01DK131446 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2022 to 2025
$1.6M
The direct regulation of feeding-driving hypothalamic GABAergic neurons on stress responsesR21MH133228 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XU, YUANZHONG · 2024 to 2025
$429k
NICHD NIH HHS U54 HD083092NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK131446NIDDK NIH HHS R01 DK135212NIDDK NIH HHS R01 DK136284NIMH NIH HHS R21 MH133228U.S. Department of Defense (United States Department of Defense) HT94252310156U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK109934U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK131446U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK135212U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK136284
6 · The paper itself

Abstract

Stress and diet are known to synergistically promote risks of obesity but the underlying neural basis remains elusive. Corticotropin-releasing hormone neurons in the paraventricular hypothalamus (PVH

Indexed as

Corticotropin-Releasing HormoneGlutamic AcidNeuronsNeurotransmitter AgentsObesityParaventricular Hypothalamic NucleusAnimalsBody WeightDiet, High-FatMaleMiceMice, Inbred C57BLCorticotropin-Releasing HormoneGlutamic AcidNeurotransmitter Agents

Identifiers

PMID42129178
PMCPMC13376941

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.