ArticleScientific reports2026
Profiling metabolites of Ficus natalensis hochst. fruit by UPLC-MS/MS and evaluation of anti-inflammatory activity.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ficus natalensis (Natal fig), an evergreen tree of the family Moraceae, is widely distributed across tropical and temperate regions and cultivated in Egypt. Members of the Moraceae family are traditionally employed as expectorants, hypoglycemic agents, and mild laxatives, with reported neuroprotective, analgesic, anti-inflammatory, and antihypertensive effects. The present study aimed to profile the secondary metabolites of F. natalensis fruit using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) and test its anti-inflammatory potential. A total of 160 metabolites were annotated in both positive and negative ionization modes, belonging to diverse phytochemical classes such as phenolics (41), flavonoids (21), acids (26), glycosides (11), terpenoids, coumarins (4), iridoids (3), fatty acids/ester (22), sterols (8), sugar derivatives (6), and terpenoids (18). The anti-inflammatory activity of F. natalensis fruit methanolic extract was investigated using nitric acid (NO) inhibition assay, revealing an IC
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