Evidence map›Paper›PMID 42129485›Full record

ReviewNature protocols2026

Flexible high-resolution ECM micropatterning.

Alessandro Gandin, Veronica Torresan, Tito Panciera, Gianluca Grenci, Giada Vanni, Anna Citron, Matteo Marchionni, Giusy Battilana, Margherita Pelosin, Rebecca Busetto and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessandro Gandin *Department of Industrial Engineering, University of Padova, Padova, Italy. alessandro.gandin@unipd.it.ORCID http://orcid.org/0000-0002-0522-2695
Veronica Torresan *Department of Industrial Engineering, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-2126-8554
Tito PancieraDepartment of Molecular Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-9272-5716
Gianluca GrenciMechanobiology Institute, National University of Singapore, Singapore, Republic of Singapore.ORCID http://orcid.org/0000-0001-9313-6748
Giada VanniDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Anna CitronDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Matteo MarchionniDepartment of Molecular Medicine, University of Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-1163-3466
Giusy BattilanaDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Margherita PelosinDepartment of Industrial Engineering, University of Padova, Padova, Italy.
Rebecca BusettoDepartment of Industrial Engineering, University of Padova, Padova, Italy.
Stefano PiccoloDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Giovanna BrusatinDepartment of Industrial Engineering, University of Padova, Padova, Italy. giovanna.brusatin@unipd.it.ORCID http://orcid.org/0000-0002-5219-8376

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial cues and cell-cell interactions within in vivo tissue architecture generate physical signals that regulate cell behavior. These mechanical interactions drive processes such as morphogenesis, homeostasis, regeneration and disease progression. To recapitulate these spatial niches in vitro, lithographic micropatterning allows for precise control over the geometry, composition, topography and mechanics of cell-adhesive substrates. Micropatterned cultures have been essential in uncovering key mechanotransduction mechanisms, including YAP/TAZ-mediated signaling, mechanoregulation in cancer, aging and early embryonic development. However, accessible and adaptable micropatterning protocols for conventional cell biology laboratories remain limited. In this protocol, we present a comprehensive procedure for generating flexible, high-resolution micropatterns (down to 10 × 10 µm

Identifiers

PMID42129485

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.