Evidence map›Paper›PMID 42129582›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026

Development and Validation of NICVD-NQ Score for Predicting Short-Term Outcomes After Primary PCI.

Rajesh Kumar, Ali Ammar, Maria Noor Siddiqui, Kubra Rahooja, Maryam Samad, Danish Qayum, Romana Awan, Mustajab Mujtaba, Ali Bin Naseer, Muhammad Rasool and 10 more

Abstract readValidation Study
In one paragraph

Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Rajesh KumarNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.ORCID https://orcid.org/0000-0002-6580-7193
Ali AmmarNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Maria Noor SiddiquiNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Kubra RahoojaNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Maryam SamadNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Danish QayumNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Romana AwanNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Mustajab MujtabaNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Ali Bin NaseerNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Muhammad RasoolNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Abiha UroojNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Rameez AhmedNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Muhammad Farhan AliNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Abdul Hakeem ShaikhNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Ayaz MirNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Nadeem QamarNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Tahir SaghirNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Jawaid Akbar SialNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
Musa KarimNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.ORCID https://orcid.org/0000-0001-7941-8191
Abdul HakeemNational Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite advances in primary percutaneous coronary intervention (PCI), patients with ST-elevation myocardial infarction (STEMI) continue to experience major adverse cardiovascular events (MACE) in the contemporary era. Existing risk scores (TIMI, GRACE, PAMI, CADILLAC) are outdated, mortality-focused, and largely derived in the fibrinolytic era from high-income settings, limiting their global relevance.

aimsThis prospective study aimed to develop a novel model to predict short-term (approximately 8 months) MACE after primary PCI.

methodsSTEMI patients presenting at the largest cardiac care center in Pakistan were prospectively enrolled to develop a model for predicting short-term (approximately 8 months) MACE. The predictive performance of the newly developed model was compared with the existing scores in the 20% testing cohort.

resultsThe complete cohort comprised 2839 patients, of whom 2250 (79.3%) were men, with a mean age of 55.6 ± 11.2 years. A total of 580 patients (20.4%) were randomly assigned to the testing cohort. At a median follow-up of 244 [175-393] days, MACE was documented in 521 patients (18.4%), with 97 (16.7%) in the testing cohort and 424 (18.8%) in the training cohort. The new additive model yielded an AUC of 0.772 [95% CI: 0.72-0.83] with the NRI (net reclassification improvement) of 0.239 (p = 0.003), 0.268 (p = 0.001), 0.086 (p = 0.322), and 0.061 (p = 0.445) against TIMI, PAMI, CADILLAC, and GRACE scores, respectively.

conclusionsThe NICVD predictive instrument outperformed the existing TIMI and PAMI scores and showed accuracy comparable to that of the GRACE and CADILLAC scores in predicting short-term MACE after primary PCI. And the model's enhanced predictive accuracy makes it a valuable tool for clinicians, enabling more enhanced risk stratification of STEMI patients.

Indexed as

Decision Support TechniquesPercutaneous Coronary InterventionST Elevation Myocardial InfarctionAgedFemaleHumansMaleMiddle AgedPakistanPredictive Value of TestsProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeMACEPCIrisk stratificationSouth AsianSTEMI

Identifiers

PMID42129582
PMCPMC13432464

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.