Trial reportBMC oral health2026
The effect of anti-tumor necrosis factor-alpha and nonsurgical periodontal therapy in individuals with rheumatoid arthritis.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06818045 (Investigation of the Effect of Nonsurgical Periodontal Treatment Applied Together With Anti-TNF-α on Alveolar Bone Loss and Oxidative Stress in Patients With Rheumatoid Arthritis and Periodontitis), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effect of Nonsurgical Periodontal Treatment Applied Together With Anti-TNF-α on Alveolar Bone Loss and Oxidative Stress in Patients With Rheumatoid Arthritis and Periodontitis
Who cites it
1 citing paper in PubMed.
- LPS-Induced TNF-α and IL-1 Signaling in Periodontitis: Molecular Mechanisms and Therapeutic Opportunities.Current issues in molecular biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundTNF-α inhibitors (anti-TNF-α) decrease the amount of inflammatory cells, osteoclast formation, and bone loss. The purpose of this study was to investigate the effect of non-surgical periodontal therapy (NSPT) combined with anti-TNF-α on oxidative stress in individuals with RA and periodontitis.
methodsA total of 42 patients with RA and periodontitis who were treated with anti-TNF-α (n = 21) and not treated with anti-TNF-α (n = 21) were included in the study. Plaque index (PI), bleeding on probing (BOP), gingival index (GI), clinical attachment loss (CAL), and probing pocket depth (PPD) measurements were measured at baseline, at 3 months, and at 6 months after NSPT, and serum and gingival crevicular fluid (GCF) samples were obtained from the patients. RANKL/OPG, MMP-8, MDA, GSH, and OSI levels were evaluated using ELISA.
resultsIn both groups, baseline PI, BOP, GI, PPD, and CAL decreased significantly after NSPT (p < 0.05). The GCF RANKL/OPG ratio was statistically significantly lower in anti-TNF-α treated patients at baseline and at 6 months post-NSPT (p < 0.05), and the serum OSI was significantly higher in anti-TNF-α treated patients at baseline (p < 0.05). GCF MMP-8 increased significantly after NSPT in both groups compared with baseline (p < 0.05). In those treated with anti-TNF-α, OSI and MDA decreased significantly after NSPT (p < 0.05).
conclusionsThe data from this study suggest that anti-TNF-α therapy can suppress inflammation and alveolar bone resorption by affecting the RANKL/OPG ratio, MMP-8, and oxidative stress parameters, and thus increase the effectiveness of NSPT.
trial registrationThis study was retrospectively registered on ClinicalTrials.gov (NCT06818045), 2025-02-02.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.